Title: Determination of solubility
1. Objective: Determination of solubility of powder and liquid.
2. Principle: The approximate solubility’s of the articles of the Pharmacopoeia are given here primarily as Information; they are not meant to be test for identifying the materials. However they may indirectly help in the primary evaluation of the integrity of an article
3. Procedure:
3.1 Solubility of powder and liquid:
A test for solubility becomes a test for purity only when where a special quantitative test is given in the individual monograph and is an official requirement.
They have been indicated by descriptive terms in the accompanying table and with reference to a temperature of 15°C to 30°C
| Descriptive term | Parts of solvent required for part of solute |
| Very soluble | Less than 1 |
| Freely soluble | From 1 to 10 |
| soluble | From 10 to 30 |
| Sparingly soluble | From 30 to 100 |
| Slightly soluble | From 100 to 1000 |
| Very Slightly soluble | From 1000 to 10,000 |
| Practically insoluble, or Insoluble | From 10,000 to more |
“End of Document”