Relative Response Factor (RRF)

Relative Response Factor (RRF)

Relative Response Factor (RRF) formula compares the detector response (usually peak area) of an impurity to the main Active Pharmaceutical Ingredient (API) at equal concentrations, crucial for accurate impurity quantification; the core formula is

RRF = Response(Impurity) / Response(API),

often expressed as;

RRF = (Area Impurity / Area API) × (Conc API / Conc Impurity)

or derived from slopes