{"id":804,"date":"2025-06-14T15:16:24","date_gmt":"2025-06-14T15:16:24","guid":{"rendered":"https:\/\/pharmacoguide.com\/?p=804"},"modified":"2025-06-14T15:16:24","modified_gmt":"2025-06-14T15:16:24","slug":"sop-title-operation-cleaning-and-calibration-of-ultrasonic-cleaner","status":"publish","type":"post","link":"https:\/\/pharmacoguide.com\/?p=804","title":{"rendered":"SOP Title: Operation, Cleaning and Calibration of Ultrasonic Cleaner"},"content":{"rendered":"

SOP Title:<\/u><\/strong> Operation, Cleaning and Calibration of Ultrasonic Cleaner<\/u><\/strong><\/p>\n

    \n
  1. Objective:<\/strong><\/li>\n<\/ol>\n

    To lay down the procedure for Operation, Cleaning and Calibration of Ultrasonic Cleaner.<\/p>\n

      \n
    1. Scope:<\/strong><\/li>\n<\/ol>\n

      This SOP is applicable for Operation, Cleaning and Calibration of Ultrasonic Cleaner located in Quality Control Laboratory.<\/p>\n

      \u00a0<\/strong><\/p>\n

        \n
      1. Responsibility:<\/strong><\/li>\n<\/ol>\n
          \n
        • Quality Control: To prepare and review the SOP. To follow the procedures laid down for Operation, Cleaning and Calibration of Ultrasonic Cleaner as per this SOP.<\/li>\n
        • Engineering Department: To carry out preventive maintenance as per schedule and procedure defined.<\/li>\n
        • Quality Assurance Department: To review and approve the SOP and Annexures.<\/li>\n<\/ul>\n

          \u00a0<\/strong><\/p>\n

            \n
          1. Accountability:<\/strong><\/li>\n<\/ol>\n

            Head Quality Control Department, Head Quality Assurance Department.<\/p>\n

              \n
            1. Procedure:<\/strong><\/li>\n<\/ol>\n

              \u00a0<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
              5.1<\/strong><\/td>\nSafety Precautions\/Instructions:<\/strong><\/td>\n<\/tr>\n
              5.1.1<\/td>\nBefore starting the sonicator, check that the sonicator is not empty.<\/td>\n <\/td>\n<\/tr>\n
              5.1.2<\/td>\nFill up the sonicator with purified water at a level of 1 inch from inside tank top.<\/td>\n <\/td>\n<\/tr>\n
              5.1.3<\/td>\nWear personal protective equipments such as safety glasses, hand gloves during operation of equipment.<\/td>\n <\/td>\n<\/tr>\n
              5.1.4<\/td>\nEnsure that the ON\/OFF switch is working properly by switching \u201cON\u201d the Ultrasonic Cleaner.\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/strong><\/td>\n <\/td>\n<\/tr>\n
              5.1.5<\/td>\nDo not touch the water surface, when the sonication is going on.<\/td>\n <\/td>\n<\/tr>\n
               <\/td>\nIntroduction To Keys<\/strong><\/td>\n<\/tr>\n
              5.1.6<\/td>\nON\/OFF\u2192To Start and to Stop the instrument.<\/p>\n

              SET TIME-\u00a0 \u00a0\u2227\u00a0 \u00a0 \u00a0\u2192will increase the time of the cycle.<\/p>\n

              \u2228 \u00a0 \u00a0\u2192will decrease the time of the cycle.<\/p>\n

              OFF\/ON HEATER \u2192To ON\/OFF the heater.<\/td>\n

              		 <\/td>\n<\/tr>\n
              5.2<\/strong><\/td>\nOperation:<\/strong><\/td>\n<\/tr>\n
              5.2.1<\/td>\nCheck the validity of Calibration before starting any operations.<\/td>\n <\/td>\n<\/tr>\n
              5.2.2<\/td>\nSwitch ON the mains. Switch on \u201cPOWER\u201d switch of equipment with the indication of green light comes on.<\/td>\n <\/td>\n<\/tr>\n
              5.2.3<\/td>\nIn order to obtain the maximum efficiency, degas the purified water in the tank for about five minutes.<\/td>\n\u00a0<\/strong><\/td>\n<\/tr>\n
              5.2.4<\/td>\nSet the required time cycle in minutes by pressing UP or DOWN keys of set time button.<\/td>\n <\/td>\n<\/tr>\n
              5.2.5<\/td>\nUP – (\u2227 ) key will increase the time of the cycle and DOWN-(\u2228 ) key\u00a0 will decrease the time of the cycle.<\/td>\n <\/td>\n<\/tr>\n
              5.2.6<\/td>\nInsert samples in the flask or glass beaker to be sonicate on mesh stand and press start button.<\/td>\n <\/td>\n<\/tr>\n
              5.2.7<\/td>\nWhen the display shows zero the equipment will shut \u2013 OFF automatically.<\/td>\n <\/td>\n<\/tr>\n
              5.2.8<\/td>\nSwitch ON the heater by pressing ON\/OFF key of the heater.<\/td>\n <\/td>\n<\/tr>\n
              5.2.9<\/td>\nThe temperature is displayed on the screen.<\/td>\n <\/td>\n<\/tr>\n
              5.2.10<\/td>\nRemove the sample from the sonicator.<\/td>\n <\/td>\n<\/tr>\n
              5.2.11<\/td>\nSwitch OFF the unit and disconnect from main switch.<\/td>\n <\/td>\n<\/tr>\n
              5.3<\/strong><\/td>\nCleaning Procedure:<\/strong><\/td>\n<\/tr>\n
              5.3.1<\/td>\nCleaning shall be done at the end of the shift.<\/td>\n <\/td>\n<\/tr>\n
              5.3.2<\/td>\nDisconnect from main supply from the unit.<\/td>\n <\/td>\n<\/tr>\n
              5.3.3<\/td>\nDrain off the water completely from the tap provided at the backside of the sonicator.<\/td>\n <\/td>\n<\/tr>\n
              5.3.4<\/td>\nClean the chamber with wet cloth to remove debris and finally dry the chamber with lint free cloth.<\/td>\n <\/td>\n<\/tr>\n
              5.4<\/strong><\/td>\nCalibration Procedure:<\/strong><\/td>\n<\/tr>\n
               <\/td>\nFrequency: <\/strong>\u00a0<\/strong>Once in a year by external agency.<\/td>\n <\/td>\n<\/tr>\n
              5.4.1<\/td>\nCalibration is carried out by external agency as per SOP \u201cCalibration of Instruments and Equipments\u201d.<\/td>\n <\/td>\n<\/tr>\n
              5.4.2<\/td>\nRefer Annexure for calibration test to be performed and acceptance criteria.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
              S<\/strong>r. No.<\/strong><\/td>\nTests<\/strong><\/td>\nSet value<\/strong><\/td>\nAcceptance Criteria <\/strong><\/td>\n<\/tr>\n
              1.<\/td>\nTemperature Verification<\/td>\n25o<\/sup>C<\/td>\n\u00a0\u00b1 2o<\/sup>C<\/td>\n<\/tr>\n
              30o<\/sup>C<\/td>\n\u00b1 2o<\/sup>C<\/td>\n<\/tr>\n
              50o<\/sup>C<\/td>\n\u00b1 2o<\/sup>C<\/td>\n<\/tr>\n
              2.<\/td>\nTimer Verification<\/td>\n05 min<\/td>\n\u00b1 1min<\/td>\n<\/tr>\n
              10 min<\/td>\n\u00b1 1min<\/td>\n<\/tr>\n
              20 min<\/td>\n\u00b1 1min<\/td>\n<\/tr>\n
              30 min<\/td>\n\u00b1 1min<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n <\/td>\n<\/tr>\n
              5.4.3<\/td>\nGenerate the A. R. No. on the \u201cInstrument\/Equipment Calibration Register\u201d as per SOP and give requisition to QA department for calibration formats of instruments\/equipments on the due date of calibration.<\/td>\n <\/td>\n<\/tr>\n
              5.4.4<\/td>\nFor issuance of calibration report refer \u201cControl of documents, Preparation, Approval, Issuance and Maintenance.<\/td>\n <\/td>\n<\/tr>\n
              5.4.5<\/td>\nIf any breakdown occurs, follow procedure as per SOP \u201cCalibration of Instruments and Equipments\u201d.<\/td>\n <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

               <\/p>\n

              \u00a0<\/strong><\/p>\n

                \n
              1. Definitions <\/strong>\/ Abbreviations:<\/strong><\/li>\n<\/ol>\n
                  \n
                • Definitions:<\/strong><\/li>\n
                • Breakdown: Any activity leading to operation of equipment other than the set parameters and\/ or unusual sound or vibration observed in the instrument\/equipment.<\/li>\n
                • Calibration: Tests performed to ensure that the instrument\/equipment is functioning as per set parameters. These tests are performed as per predefined frequency and also after any major repair or replacement of parts.<\/li>\n<\/ul>\n

                  \u00a0<\/strong><\/p>\n

                    \n
                  • Abbreviations:<\/strong><\/li>\n<\/ul>\n\n\n\n\n\n\n\n\n
                    Abbreviation<\/strong><\/td>\nExpansion<\/strong><\/td>\n<\/tr>\n
                    SOP<\/td>\nStandard Operating Procedure<\/td>\n<\/tr>\n
                    QC<\/td>\nQuality Control<\/td>\n<\/tr>\n
                    QA<\/td>\nQuality Assurance<\/td>\n<\/tr>\n
                    mm<\/td>\nmillimetre<\/td>\n<\/tr>\n
                    A. R. No.<\/td>\nAnalytical Reference Number<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

                     <\/p>\n

                    *Note – Ready to use SOP available in \u201cDOWNLOAD\u201d Section.<\/u><\/em><\/strong><\/p>\n

                     <\/p>\n","protected":false},"excerpt":{"rendered":"

                    SOP Title: Operation, Cleaning and Calibration of Ultrasonic Cleaner Objective: To lay down the procedure for Operation, Cleaning and Calibration of Ultrasonic Cleaner. Scope: This SOP is applicable for Operation, Cleaning and Calibration of Ultrasonic Cleaner located in Quality Control Laboratory. \u00a0 Responsibility: Quality Control: To prepare and review the SOP. To follow the procedures […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"templates\/template-full-width.php","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-804","post","type-post","status-publish","format-standard","hentry","category-qc-sop"],"_links":{"self":[{"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=\/wp\/v2\/posts\/804","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=804"}],"version-history":[{"count":1,"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=\/wp\/v2\/posts\/804\/revisions"}],"predecessor-version":[{"id":805,"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=\/wp\/v2\/posts\/804\/revisions\/805"}],"wp:attachment":[{"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=804"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=804"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=804"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}