{"id":797,"date":"2025-06-14T14:38:10","date_gmt":"2025-06-14T14:38:10","guid":{"rendered":"https:\/\/pharmacoguide.com\/?p=797"},"modified":"2025-06-14T14:38:10","modified_gmt":"2025-06-14T14:38:10","slug":"sop-title-operation-cleaning-and-calibration-of-muffle-furnace","status":"publish","type":"post","link":"https:\/\/pharmacoguide.com\/?p=797","title":{"rendered":"SOP Title: Operation, Cleaning and Calibration of Muffle Furnace"},"content":{"rendered":"

SOP Title:<\/u><\/strong> Operation, Cleaning and Calibration of Muffle Furnace<\/u><\/strong><\/p>\n

    \n
  1. Objective:<\/strong><\/li>\n<\/ol>\n

    To lay down the procedure for Operation, Cleaning and Calibration of Muffle Furnace.<\/p>\n

      \n
    1. Scope:<\/strong><\/li>\n<\/ol>\n

      This SOP is applicable for Operation, Cleaning and Calibration of Muffle Furnace located in Quality Control Laboratory<\/p>\n

      \u00a0<\/strong><\/p>\n

        \n
      1. Responsibility:<\/strong><\/li>\n<\/ol>\n
          \n
        • Quality Control: To prepare and review the SOP. To follow the procedures laid down for Operation, Cleaning and Calibration of Muffle Furnace as per this SOP.<\/li>\n
        • Engineering Department: To carry out preventive maintenance as per schedule and procedure defined.<\/li>\n
        • Quality Assurance Department: To review and approve the SOP and Annexures.<\/li>\n<\/ul>\n

          \u00a0<\/strong><\/p>\n

            \n
          1. Accountability:<\/strong><\/li>\n<\/ol>\n

            Head Quality Control Department, Head Quality Assurance Department.<\/p>\n

             <\/p>\n

              \n
            1. Procedure:<\/strong><\/li>\n<\/ol>\n

              \u00a0<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
              \u00a0\u00a0\u00a0 5.1<\/strong><\/td>\nSafety Precautions\/Instructions:<\/strong><\/td>\n<\/tr>\n
              5.1.1<\/td>\nEnsure all the electrical connections are properly earthed. Ensure the power plug of the muffle furnace is fixed in the socket properly.<\/td>\n <\/td>\n<\/tr>\n
              5.1.2<\/td>\nWear personal protective equipments such as safety glasses, heat resistant gloves during operation of equipment.<\/td>\n <\/td>\n<\/tr>\n
              5.1.3<\/td>\nEnsure that the ON\/OFF switch is working properly by switching \u201cON\u201d the muffle furnace.\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/strong><\/td>\n <\/td>\n<\/tr>\n
              \u00a0\u00a0\u00a0 5.2<\/strong><\/td>\nOperation:<\/strong><\/td>\n<\/tr>\n
              5.2.1<\/td>\nSwitch ON the main switch.<\/td>\n <\/td>\n<\/tr>\n
              5.2.2<\/td>\nThe main indicator red light and yellow light will glow and the temperature panel display will show the temperature in o <\/sup>C.<\/td>\n <\/td>\n<\/tr>\n
              5.2.3<\/td>\nSet the required temperature on the digital temperature controller by pushing red key present at the left side of \u201cTemp. SET\u201d knob and rotating the \u201cTemp. SET\u201d knob.<\/td>\n <\/td>\n<\/tr>\n
              5.2.4<\/td>\nRelieve the red key button after the required temperature is set.<\/td>\n <\/td>\n<\/tr>\n
              5.2.5<\/td>\nMove the \u201cEnergy Regulator\u201d knob clockwise to corresponding temperature.<\/td>\n <\/td>\n<\/tr>\n
              5.2.6<\/td>\nWait till the temperature controller display shows the set temperature.<\/td>\n <\/td>\n<\/tr>\n
              5.2.7<\/td>\nOpen the door of the muffle furnace by pushing the lever upwards and place the crucible containing sample inside the muffle furnace with the help of long pair of tongs.<\/td>\n <\/td>\n<\/tr>\n
              5.2.8<\/td>\nImmediately close the door.<\/td>\n <\/td>\n<\/tr>\n
              5.2.9<\/td>\nAllow the substance under test to remain inside muffle furnace at a specified temperature and specified time as mentioned in the respective pharmacopoeia or specification.<\/td>\n <\/td>\n<\/tr>\n
              5.2.10<\/td>\nAfter completion of analysis, Switch OFF the mains of the muffle furnace.<\/td>\n <\/td>\n<\/tr>\n
              5.2.11<\/td>\nOpen the door of the muffle furnace, remove the crucible containing sample and place it in desiccator till it attains the room temperature.<\/td>\n\u00a0<\/strong><\/td>\n<\/tr>\n
              5.2.12<\/td>\nImmediately close the door of the muffle furnace.<\/td>\n <\/td>\n<\/tr>\n
              5.2.13<\/td>\nUpdate the \u201cInstrument\/Equipment Usage Log Book\u201d as per SOP \u201cCalibration of Instruments and Equipment\u2019s\u201d.<\/td>\n <\/td>\n<\/tr>\n
              5.3<\/strong><\/td>\nCleaning Procedure:<\/strong><\/td>\n<\/tr>\n
              5.3.1<\/td>\nSwitch OFF the mains of the muffle furnace.<\/td>\n <\/td>\n<\/tr>\n
              5.3.2<\/td>\nEnsure that the temperature of the muffle furnace is nearly at room temperature when cleaning inside.<\/td>\n <\/td>\n<\/tr>\n
              5.3.3<\/td>\nClean the inside and outside of muffle furnace with lint free cloth or soft brush before and after use.<\/td>\n <\/td>\n<\/tr>\n
              5.4<\/strong><\/td>\nCalibration Procedure:<\/strong><\/td>\n<\/tr>\n
               <\/td>\nFrequency: <\/strong>\u00a0<\/strong>Once in a year by external agency.<\/td>\n<\/tr>\n
              5.4.1<\/td>\nCalibration is carried out by external agency as per SOP \u201cCalibration of Instruments and Equipment\u2019s\u201d.<\/td>\n <\/td>\n<\/tr>\n
              5.4.2<\/td>\nRefer Annexure for calibration test to be performed and acceptance criteria.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
              Sr. No.<\/strong><\/td>\nTests<\/strong><\/td>\nSet value<\/strong><\/td>\nAcceptance Criteria <\/strong><\/p>\n

              (\u00b1 2%)<\/strong><\/td>\n<\/tr>\n

              1.<\/td>\nTemperature Verification<\/td>\n200o<\/sup>C<\/td>\n\u00b1 4o<\/sup>C<\/td>\n<\/tr>\n
              400\u00b0C<\/td>\n\u00b1 8o<\/sup>C<\/td>\n<\/tr>\n
              800o<\/sup>C<\/td>\n\u00b1 16o<\/sup>C<\/td>\n<\/tr>\n
              1000o<\/sup>C<\/td>\n\u00b1 20o<\/sup>C<\/td>\n<\/tr>\n
              1100o<\/sup>C<\/td>\n\u00b1 22o<\/sup>C<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n <\/td>\n<\/tr>\n
              5.4.3<\/td>\nGenerate the A. R. No. on the \u201cInstrument\/Equipment Calibration Register\u201d as per SOP and give requisition to QA department for calibration formats of instruments\/equipments on the due date of calibration.<\/td>\n <\/td>\n<\/tr>\n
              5.4.4<\/td>\nFor issuance of calibration report refer SOP \u201cControl of documents, Preparation, Approval, Issuance and Maintenance.<\/td>\n <\/td>\n<\/tr>\n
              5.4.5<\/td>\nUpdate \u201cAnnual Calibration Schedule\u201d and \u201cMonthly Calibration Schedule\u201d as per SOP \u201cCalibration of Instruments and Equipments\u201d.<\/td>\n <\/td>\n<\/tr>\n
              5.5<\/strong><\/td>\nPreventive Maintenance:<\/strong><\/td>\n<\/tr>\n
              5.5.1<\/td>\nPerform the preventive maintenance as per define Annexure.<\/td>\n <\/td>\n<\/tr>\n
              5.5.2<\/td>\nIf preventive maintenance activity is outsourced, the observations are to be transcribed in the Annexure and external party certificate to be attached.<\/td>\n <\/td>\n<\/tr>\n
              5.5.3<\/td>\nIf any breakdown occurs, follow procedure as per SOP \u201cCalibration of Instruments and Equipments\u201d.<\/td>\n <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

              \u00a0<\/strong><\/p>\n

                \n
              1. Definitions<\/strong> \/ Abbreviations:<\/strong><\/li>\n<\/ol>\n
                  \n
                • Definitions:<\/strong><\/li>\n
                • Calibration: Tests performed to ensure that the instrument\/equipment is functioning as per set parameters. These tests are performed as per predefined frequency and also after any major repair or replacement of parts.<\/li>\n
                • Preventive Maintenance: Maintenance activity performed to ensure that the equipment will function smoothly and to avoid breakdowns. These activities are performed as per predefined frequency.<\/li>\n
                • Abbreviations<\/strong><\/li>\n<\/ul>\n

                  \u00a0<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n
                  Abbreviation<\/strong><\/td>\nExpansion<\/strong><\/td>\n<\/tr>\n
                  SOP<\/td>\nStandard Operating Procedure<\/td>\n<\/tr>\n
                  QC<\/td>\nQuality Control<\/td>\n<\/tr>\n
                  QA<\/td>\nQuality Assurance<\/td>\n<\/tr>\n
                  A. R. No<\/td>\nAnalytical Reference Number<\/td>\n<\/tr>\n
                  No.<\/td>\nNumber<\/td>\n<\/tr>\n
                  o<\/sup>C<\/td>\nDegree Celsius<\/td>\n<\/tr>\n
                  PM<\/td>\nPreventive Maintenance<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

                   <\/p>\n

                  *Note – Ready to use SOP available in \u201cDOWNLOAD\u201d Section.<\/u><\/em><\/strong><\/p>\n

                   <\/p>\n","protected":false},"excerpt":{"rendered":"

                  SOP Title: Operation, Cleaning and Calibration of Muffle Furnace Objective: To lay down the procedure for Operation, Cleaning and Calibration of Muffle Furnace. Scope: This SOP is applicable for Operation, Cleaning and Calibration of Muffle Furnace located in Quality Control Laboratory \u00a0 Responsibility: Quality Control: To prepare and review the SOP. To follow the procedures […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"templates\/template-full-width.php","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-797","post","type-post","status-publish","format-standard","hentry","category-qc-sop"],"_links":{"self":[{"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=\/wp\/v2\/posts\/797","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=797"}],"version-history":[{"count":1,"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=\/wp\/v2\/posts\/797\/revisions"}],"predecessor-version":[{"id":798,"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=\/wp\/v2\/posts\/797\/revisions\/798"}],"wp:attachment":[{"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=797"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=797"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=797"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}