{"id":2852,"date":"2026-01-08T06:39:58","date_gmt":"2026-01-08T06:39:58","guid":{"rendered":"https:\/\/pharmacoguide.com\/?p=2852"},"modified":"2026-01-08T06:39:58","modified_gmt":"2026-01-08T06:39:58","slug":"determination-of-uniformity-weight-as-per-ip","status":"publish","type":"post","link":"https:\/\/pharmacoguide.com\/?p=2852","title":{"rendered":"Determination of uniformity weight (As Per IP)"},"content":{"rendered":"
Title:<\/strong> Determination of uniformity weight<\/strong><\/em><\/span><\/h5>\n

 <\/p>\n

1.\u00a0\u00a0\u00a0\u00a0\u00a0 Objective:<\/strong> Determination of uniformity weight tablets, capsules and powders as per IP.<\/p>\n

 <\/p>\n

2.\u00a0\u00a0\u00a0\u00a0\u00a0 Principle:<\/strong> \u00a0\u00a0The test for uniformity of weight of single-dose preparations\u00a0is based on the individual single-dose units to determine\u00a0whether the individual unit weight are within limits set with\u00a0reference to the average content of the sample.<\/p>\n

\u00a03. <\/strong>Procedure:<\/strong><\/p>\n

3.1 <\/strong>Uniformity weight tablets, capsules and powders:<\/strong><\/p>\n

Weigh individually 20 units selected at random or, for single dose\u00a0preparations in individual containers, the contents of\u00a020 units, and calculate the average weight. Not more than two\u00a0of the individual weights deviate from the average weight by\u00a0more than the percentage shown in the table and none deviates\u00a0by more than twice that percentage.<\/p>\n

 <\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Dosage<\/strong><\/p>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 form<\/strong><\/td>\n

Average weight<\/strong><\/td>\nPercentage deviation<\/strong><\/td>\nNumber of tablets<\/strong><\/td>\n<\/tr>\n
Uncoated<\/p>\n

and film coated<\/p>\n

tablets<\/p>\n

\u00a0<\/em><\/strong><\/td>\n

80 mg or less<\/td>\n\u00b1\u00a0 10<\/td>\n18<\/td>\n<\/tr>\n
\u00b1 \u00a020<\/td>\n\u00a02<\/td>\n<\/tr>\n
More than 80 mg but less than 250 mg<\/td>\n\u00b1 \u00a07.5<\/td>\n\u00a08<\/td>\n<\/tr>\n
\u00b1\u00a0 15<\/td>\n\u00a02<\/td>\n<\/tr>\n
250 mg or more<\/td>\n\u00b1\u00a0 5<\/td>\n18<\/td>\n<\/tr>\n
\u00b1\u00a0 10<\/td>\n\u00a02<\/td>\n<\/tr>\n
Capsules, granules and powders(single dose)<\/td>\nLess than 300 mg<\/td>\n\u00b1 \u00a010<\/td>\n18<\/td>\n<\/tr>\n
\u00b1 \u00a020<\/td>\n\u00a02<\/td>\n<\/tr>\n
300 mg or more<\/td>\n\u00b1 \u00a07.5<\/td>\n18<\/td>\n<\/tr>\n
\u00b1 \u00a015<\/td>\n\u00a02<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n
Dosage<\/strong><\/p>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 form<\/strong><\/td>\n

Average weight<\/strong><\/td>\nPercentage deviation<\/strong><\/td>\nNumber of tablets<\/strong><\/td>\n<\/tr>\n
Powders for parenteral use<\/td>\nMore than 40 mg<\/td>\n\u00b1 10<\/td>\n18<\/td>\n<\/tr>\n
\u00b1 20<\/td>\n\u00a02<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00a0<\/em><\/strong><\/p>\n

\u00a0\u00a0\u00a0 For capsules\u00a0<\/strong><\/p>\n

Weigh an intact capsule. Open it without losing\u00a0any part of the shell and remove the contents as completely\u00a0as possible. For soft gelatin\u00a0capsules, wash the shell with a\u00a0suitable solvent and keep aside until the odour of the solvent\u00a0is not perceptible. Weigh the shell. The difference between\u00a0the weighing gives the weight of the contents. Repeat the\u00a0procedure with another 19 capsules.<\/p>\n

For powders for <\/strong>parenteral use<\/strong><\/p>\n

Remove any adhering labels\u00a0from a container and wash and dry the outside. Open the\u00a0container and immediately weigh it along with the contents.\u00a0Empty it as completely as possible by gentle tapping, rinse it\u00a0with\u00a0water\u00a0<\/em>and then with\u00a0ethanol.\u00a0<\/em>Dry at 100\u00b0C to 105\u00b0C for one\u00a0hour, or if the nature of the contents does not permit drying at\u00a0this temperature, dry at a lower temperature to constant weight.\u00a0Cool in a\u00a0desiccator\u00a0and weigh. The difference in the weighing\u00a0gives the weight of the contents of the container. Repeat the\u00a0procedure with another 19 containers.<\/p>\n

\u00a0<\/sub><\/p>\n

Weight of 20 unit :\u00a0 X<\/p>\n

Average weight :\u00a0\u00a0 X\/20 = Y<\/p>\n

 <\/p>\n

Y= should meet specified criteria<\/strong><\/p>\n

 <\/p>\n

\u00a0<\/strong><\/p>\n

\n

“End of Document”<\/span><\/u><\/em><\/h4>\n","protected":false},"excerpt":{"rendered":"

Title: Determination of uniformity weight   1.\u00a0\u00a0\u00a0\u00a0\u00a0 Objective: Determination of uniformity weight tablets, capsules and powders as per IP.   2.\u00a0\u00a0\u00a0\u00a0\u00a0 Principle: \u00a0\u00a0The test for uniformity of weight of single-dose preparations\u00a0is based on the individual single-dose units to determine\u00a0whether the individual unit weight are within limits set with\u00a0reference to the average content of the sample. […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"templates\/template-full-width.php","format":"standard","meta":{"footnotes":""},"categories":[41],"tags":[],"class_list":["post-2852","post","type-post","status-publish","format-standard","hentry","category-elemental-impurities"],"_links":{"self":[{"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=\/wp\/v2\/posts\/2852","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2852"}],"version-history":[{"count":1,"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=\/wp\/v2\/posts\/2852\/revisions"}],"predecessor-version":[{"id":2853,"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=\/wp\/v2\/posts\/2852\/revisions\/2853"}],"wp:attachment":[{"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2852"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2852"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2852"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}