{"id":2843,"date":"2026-01-08T05:44:42","date_gmt":"2026-01-08T05:44:42","guid":{"rendered":"https:\/\/pharmacoguide.com\/?p=2843"},"modified":"2026-01-08T05:44:42","modified_gmt":"2026-01-08T05:44:42","slug":"determination-of-solubility","status":"publish","type":"post","link":"https:\/\/pharmacoguide.com\/?p=2843","title":{"rendered":"Determination of solubility"},"content":{"rendered":"<h4><span style=\"text-decoration: underline;\"><em><strong>Title:<\/strong> <strong>Determination of solubility<\/strong><\/em><\/span><\/h4>\n<p>&nbsp;<\/p>\n<p>1.\u00a0\u00a0\u00a0\u00a0\u00a0 <strong>Objective:<\/strong> Determination of solubility of powder and liquid.<\/p>\n<p>2.\u00a0\u00a0\u00a0\u00a0\u00a0<strong> Principle:<\/strong> The approximate solubility\u2019s of the articles of the Pharmacopoeia are given here primarily as Information; they are not meant to be test for identifying the materials. However they may indirectly help in the primary evaluation of the integrity of an article<\/p>\n<p><strong>\u00a0<\/strong><strong>3. Procedure:<\/strong><\/p>\n<p><strong>3.1 \u00a0\u00a0\u00a0Solubility of powder and liquid:<\/strong><\/p>\n<p>A test for solubility becomes a test for purity only when where a special quantitative test is given in the individual monograph and is an official requirement.<\/p>\n<p>They have been indicated by descriptive terms in the accompanying table and with reference to a temperature of 15\u00b0C to 30\u00b0C<\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"289\"><strong>Descriptive term <\/strong><\/td>\n<td width=\"349\"><strong>Parts of solvent required for part of solute<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"289\">Very soluble<\/td>\n<td width=\"349\">Less than 1<\/td>\n<\/tr>\n<tr>\n<td width=\"289\">Freely soluble<\/td>\n<td width=\"349\">From\u00a0 1 to 10<\/td>\n<\/tr>\n<tr>\n<td width=\"289\">soluble<\/td>\n<td width=\"349\">From\u00a0 10 to 30<\/td>\n<\/tr>\n<tr>\n<td width=\"289\">Sparingly soluble<\/td>\n<td width=\"349\">From\u00a0 30 to 100<\/td>\n<\/tr>\n<tr>\n<td width=\"289\">Slightly soluble<\/td>\n<td width=\"349\">From\u00a0 100 to 1000<\/td>\n<\/tr>\n<tr>\n<td width=\"289\">Very Slightly soluble<\/td>\n<td width=\"349\">From\u00a0 1000 to 10,000<\/td>\n<\/tr>\n<tr>\n<td width=\"289\">Practically insoluble, or Insoluble<\/td>\n<td width=\"349\">From\u00a0 10,000 to more<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<hr \/>\n<h4 style=\"text-align: center;\" align=\"center\"><em><u><span style=\"font-size: 16.0pt; line-height: 115%;\">&#8220;End of Document&#8221;<\/span><\/u><\/em><\/h4>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Title: Determination of solubility &nbsp; 1.\u00a0\u00a0\u00a0\u00a0\u00a0 Objective: Determination of solubility of powder and liquid. 2.\u00a0\u00a0\u00a0\u00a0\u00a0 Principle: The approximate solubility\u2019s of the articles of the Pharmacopoeia are given here primarily as Information; they are not meant to be test for identifying the materials. However they may indirectly help in the primary evaluation of the integrity of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"templates\/template-full-width.php","format":"standard","meta":{"footnotes":""},"categories":[41],"tags":[],"class_list":["post-2843","post","type-post","status-publish","format-standard","hentry","category-elemental-impurities"],"_links":{"self":[{"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=\/wp\/v2\/posts\/2843","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2843"}],"version-history":[{"count":1,"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=\/wp\/v2\/posts\/2843\/revisions"}],"predecessor-version":[{"id":2844,"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=\/wp\/v2\/posts\/2843\/revisions\/2844"}],"wp:attachment":[{"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2843"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2843"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmacoguide.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2843"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}